Comments on: The Genetics of Sexual Development

By: Hsien

Hsien — Sat, 26 May 2007 20:29:35 +0000

Me? Secrets? Just check my Facebook.

By: laura

laura — Fri, 25 May 2007 15:44:09 +0000

Hsien,

great book. you have been reading some great stuff lately.

I liked it!

Of course, I don’t have your background in genetics. But it made me look at people a little differently, and think about the secrets that we are hiding.

By: Hsien

Hsien — Fri, 25 May 2007 15:22:11 +0000

Interesting!! I found the episode summary at Television Without Pity in case anyone wants to read more. Thanks for sharing, Alicia!

By: alicia

alicia — Fri, 25 May 2007 15:17:41 +0000

Thanks for the clarification! Your post reminded me of an episode of Grey’s Anatomy (that show actually teaches a little something, haha), but I didn’t mention it for two reasons. One, a London friend of mine (*cough* a singer whose song actually appeared on one of the GA episodes *cough*) told me England was behind in the episodes, and two, I thought I’d look foolish, lol.

Anyway, Addison, the resident obgyn surgeon, refuses to perform a sexual assignment surgery on a teenage “girl” who is in the hospital for some other reason. Addison finds out the girl actually has testes near her ovaries, the parents freak, don’t want her to tell their daughter, and actually ask if Addison will remove them when she’s performing the other surgery. Addison refuses and there’s this whole theme about morals and ethics and whatnot going on.

So, your post got me to thinking…if a doctor wouldn’t do it to a girl who was old enough to make her own decision, would one do it to a baby?

Too, it turned out the girl was relieved to find out she could be a boy if she wanted to – and opted to.

By: Hsien

Hsien — Fri, 25 May 2007 15:01:40 +0000

For others who are interested. An old post of mine:

In men, the SRY (sex-determining region Y) gene on the Y chromosome determines the development of male characteristics. The corresponding gene in women may be the R-spondin1 (RSPO1) gene. People with the XX genotype who would normally be women become men if they have a non-functional RSPO1 gene. The gene was discovered in a family of four sons who all had two X chromosomes, no SRY gene, and mutations in the RSPO1 gene.

By: Hsien

Hsien — Fri, 25 May 2007 15:00:05 +0000

That’s a good question, Alicia. According to the Scientific American article I linked to above, a lot of times the decisions have less to do with the patient’s genetic make-up than with the doctors’ emotions. Dr. Vilain says,

What really matters is what people feel they are in terms of gender, not what their family or doctors think they should be.

You’re very insightful!

By: alicia

alicia — Fri, 25 May 2007 14:50:43 +0000

OK, help me out here. These “chromosomes that may be involved in differential sex expression,” along with the other three you listed – are these what help doctors determine if the sexual assignment surgeries should “assign” a baby as male or female?

I’m assuming if the surgery isn’t done when the person is a baby, they can make their own decision when they’re older and realize their situation.