Comments on: Google Answers DNA – Who’s yer daddy? http://www.eyeondna.com/2007/08/16/google-answers-dna-whos-yer-daddy/ How will it change your life? Mon, 19 Jul 2010 13:56:21 +0800 http://wordpress.org/?v=2.8.4 hourly 1 By: Scott Cohn http://www.eyeondna.com/2007/08/16/google-answers-dna-whos-yer-daddy/comment-page-1/#comment-61325 Scott Cohn Wed, 01 Jul 2009 23:02:16 +0000 http://www.eyeondna.com/2007/08/16/google-answers-dna-whos-yer-daddy/#comment-61325 Hi there! Here’s the scenario in my head which brought about this line of questioning. If the biological father and mother go to court because he believes she’s cheated and wants a dna test for he and their son, and results say he isn’t the father when he actually is, what’s the course of action test wise to finally prove it? Is there a scenario in which they would test to see if he’s an actual chimera when he didn’t know to begin with? How might it come up later that he would get tested and/to prove it? Like a disease that crops up maybe? I imagine the tests are much more limited than for a woman. And I don’t imagine people immediately think “let’s see if he’s a chimera” when a test comes back negative. The father in this scenario would not be a hermaphrodite. Any and all characteristics of this would be appreciated! (i.e. Would the son have ANY characteristics of the father? Or is it his twin’s the son would share? And how does that work when the father is the chimera in a parental scenario?) Sorry, I have a million questions, but this fascinates me. I saw the show, “I am my own twin”, but they only dealt with 2 women, and the only answer I found was on here. My father ran the clinical labs at CHoP, as well as taught biochemistry at Univ of Penn, but he unfortunately didn’t know enough to answer my question. I may have to trade him in. ;) I’m sure you’re extremely busy, but if you get the chance to answer this, I’d appreciate it! Thanks! - Scott Hi there!

Here’s the scenario in my head which brought about this line of questioning. If the biological father and mother go to court because he believes she’s cheated and wants a dna test for he and their son, and results say he isn’t the father when he actually is, what’s the course of action test wise to finally prove it? Is there a scenario in which they would test to see if he’s an actual chimera when he didn’t know to begin with? How might it come up later that he would get tested and/to prove it? Like a disease that crops up maybe? I imagine the tests are much more limited than for a woman. And I don’t imagine people immediately think “let’s see if he’s a chimera” when a test comes back negative. The father in this scenario would not be a hermaphrodite.

Any and all characteristics of this would be appreciated! (i.e. Would the son have ANY characteristics of the father? Or is it his twin’s the son would share? And how does that work when the father is the chimera in a parental scenario?) Sorry, I have a million questions, but this fascinates me.

I saw the show, “I am my own twin”, but they only dealt with 2 women, and the only answer I found was on here. My father ran the clinical labs at CHoP, as well as taught biochemistry at Univ of Penn, but he unfortunately didn’t know enough to answer my question. I may have to trade him in. ;)

I’m sure you’re extremely busy, but if you get the chance to answer this, I’d appreciate it! Thanks!

- Scott

]]> By: B http://www.eyeondna.com/2007/08/16/google-answers-dna-whos-yer-daddy/comment-page-1/#comment-61250 B Tue, 12 May 2009 17:50:59 +0000 http://www.eyeondna.com/2007/08/16/google-answers-dna-whos-yer-daddy/#comment-61250 Lee dallman, We have almost the exact circumstance with my son and his biological father. I know..I was there. I have searched my mind over and over.. I hope they will forget the stupid test and just go with their gut. Lee dallman,

We have almost the exact circumstance with my son and his biological father. I know..I was there. I have searched my mind over and over..
I hope they will forget the stupid test and just go with their gut.

]]> By: Lee dallman http://www.eyeondna.com/2007/08/16/google-answers-dna-whos-yer-daddy/comment-page-1/#comment-57644 Lee dallman Sat, 09 Aug 2008 20:52:16 +0000 http://www.eyeondna.com/2007/08/16/google-answers-dna-whos-yer-daddy/#comment-57644 My husband who is 68 years old and I have located his birth daughter who is now 45 years old after searching for her for 23 years.They have had two DNA tests that have come back that he is not the birth father. The birth mother says that he definitely is. Any imput? This is causing a lot of trouble. Any help would be appreciated. Thank -you My husband who is 68 years old and I have located his birth daughter who is now 45 years old after searching for her for 23 years.They have had two DNA tests that have come back that he is not the birth father. The birth mother says that he definitely is. Any imput? This is causing a lot of trouble. Any help would be appreciated. Thank -you

]]> By: Hsien http://www.eyeondna.com/2007/08/16/google-answers-dna-whos-yer-daddy/comment-page-1/#comment-5706 Hsien Tue, 28 Aug 2007 14:46:25 +0000 http://www.eyeondna.com/2007/08/16/google-answers-dna-whos-yer-daddy/#comment-5706 Shatara, Thanks for the comment. I have no idea how often paternity tests come back with a false negative. With respect to Maury, I think some of the situations have to be staged. Shatara, Thanks for the comment. I have no idea how often paternity tests come back with a false negative. With respect to Maury, I think some of the situations have to be staged.

]]> By: Shatara http://www.eyeondna.com/2007/08/16/google-answers-dna-whos-yer-daddy/comment-page-1/#comment-5639 Shatara Tue, 28 Aug 2007 04:52:04 +0000 http://www.eyeondna.com/2007/08/16/google-answers-dna-whos-yer-daddy/#comment-5639 Although The Maury Show is certainly not a reliable source, I have to admit that I began to wonder about some of the women on the show after I learned about chimerism. I mean, really, some of them come back over and over again with more than one man at a time. It's like, ok I'm trying to do the math here, according to how many men these particular women have had tested so far, they were pretty damn busy for those 3 weeks out of the month. they would have had to sleep with at least one different guy every night of those 21 days in order to actually think all of these guys could be a potential father. Sure got me to thinking, wonder if the father was already tested and told he wasn't the father so he went on his merry way while the mother is loosing her frikin mind. I read that a sign of chimerism could be that a person has eyes that are each a different color, or patches of hair that are different colors from the rest of the hair. I personally know a guy who has one brown eye and one blue. when I was in school, there was a kid there with one brown eye and one dark gray. Get's me to thinking, what if one of these guys get's into a situation where he has a woman claiming he's the father of her child and she wants child support. he doubts her claim, so the office of child support says they will administer a dna test, it comes back negative, but he is actually the father. The father walks away happy, the mother is left confused and trying to retrace her steps, the child support office goes about it's business. Kid grows up with no father, and no one cares. I think this thing happens far more than anyone in the government would want to admint. That would mean they have to admit screwing up on countless cases where criminals were set free, or homes were broken up and/or children were left fatherless and possibly poor. The government doesn't want that, but someone should push the issue. I think it is very important. Although The Maury Show is certainly not a reliable source, I have to admit that I began to wonder about some of the women on the show after I learned about chimerism. I mean, really, some of them come back over and over again with more than one man at a time. It’s like, ok I’m trying to do the math here, according to how many men these particular women have had tested so far, they were pretty damn busy for those 3 weeks out of the month. they would have had to sleep with at least one different guy every night of those 21 days in order to actually think all of these guys could be a potential father. Sure got me to thinking, wonder if the father was already tested and told he wasn’t the father so he went on his merry way while the mother is loosing her frikin mind.
I read that a sign of chimerism could be that a person has eyes that are each a different color, or patches of hair that are different colors from the rest of the hair. I personally know a guy who has one brown eye and one blue. when I was in school, there was a kid there with one brown eye and one dark gray. Get’s me to thinking, what if one of these guys get’s into a situation where he has a woman claiming he’s the father of her child and she wants child support. he doubts her claim, so the office of child support says they will administer a dna test, it comes back negative, but he is actually the father. The father walks away happy, the mother is left confused and trying to retrace her steps, the child support office goes about it’s business. Kid grows up with no father, and no one cares.
I think this thing happens far more than anyone in the government would want to admint. That would mean they have to admit screwing up on countless cases where criminals were set free, or homes were broken up and/or children were left fatherless and possibly poor.
The government doesn’t want that, but someone should push the issue. I think it is very important.

]]> By: NA http://www.eyeondna.com/2007/08/16/google-answers-dna-whos-yer-daddy/comment-page-1/#comment-4799 NA Sat, 18 Aug 2007 02:45:44 +0000 http://www.eyeondna.com/2007/08/16/google-answers-dna-whos-yer-daddy/#comment-4799 So when should one suspect mosaicism in a genetic disorder? I looked in my genetic disorder notes and I wrote down a case about a male and a female (2 different families) that had mosaicism occur in von Hippel-Lindau. Both patients had clinical VHL disease but were negative for VHL mutations. Each and an offspring with known clinical VHL disease and both offspring had a documented germline mutation in the VHL tumor suppressor gene. I also wrote down a case Mosaicism can also be a reason why some females miscarry at the same time of embryonic development in each pregnancy (e.g., 3 months). The mother can have a karyotype done and it can come back normal, but it can also come back a turner syndrome chromosome number. So when should one suspect mosaicism in a genetic disorder? I looked in my genetic disorder notes and I wrote down a case about a male and a female (2 different families) that had mosaicism occur in von Hippel-Lindau. Both patients had clinical VHL disease but were negative for VHL mutations. Each and an offspring with known clinical VHL disease and both offspring had a documented germline mutation in the VHL tumor suppressor gene. I also wrote down a case
Mosaicism can also be a reason why some females miscarry at the same time of embryonic development in each pregnancy (e.g., 3 months). The mother can have a karyotype done and it can come back normal, but it can also come back a turner syndrome chromosome number.

]]> By: NA http://www.eyeondna.com/2007/08/16/google-answers-dna-whos-yer-daddy/comment-page-1/#comment-4754 NA Fri, 17 Aug 2007 14:11:41 +0000 http://www.eyeondna.com/2007/08/16/google-answers-dna-whos-yer-daddy/#comment-4754 "I know that’s what they said, but then they have to operate under the assumption that you don’t ever get a false positive, but a negative might always be false. They don’t know what the prevalance is of just one organ being affected, or more than one being affected." I suspect that one wouldn’t find any common prevalence for the number of organs affected in a population group. Not like you would find the prevalence of a disorder being present in a population. It all depends on which germ line the organ develops from. I advise to read up on the three germ lines and how the process of development occurs up to about week 16. “I know that’s what they said, but then they have to operate under the assumption that you don’t ever get a false positive, but a negative might always be false. They don’t know what the prevalance is of just one organ being affected, or more than one being affected.”

I suspect that one wouldn’t find any common prevalence for the number of organs affected in a population group. Not like you would find the prevalence of a disorder being present in a population. It all depends on which germ line the organ develops from. I advise to read up on the three germ lines and how the process of development occurs up to about week 16.

]]> By: NA http://www.eyeondna.com/2007/08/16/google-answers-dna-whos-yer-daddy/comment-page-1/#comment-4753 NA Fri, 17 Aug 2007 14:04:54 +0000 http://www.eyeondna.com/2007/08/16/google-answers-dna-whos-yer-daddy/#comment-4753 "No, I know what a Chimera is, what I’m saying is that so little of the general population has been tested for DNA sequencing that we don’t know how many of us are likely carrying parts of a vanished twin." This is due to DNA sequencing being very expensive and time consuming. We are only a few years passed having the human genome sequence. Time will come when our DNA sequence will cost less then 1,000 dollars and can be done as fast and as long as you want it to depending on how many SNPs that need to be sequenced. “No, I know what a Chimera is, what I’m saying is that so little of the general population has been tested for DNA sequencing that we don’t know how many of us are likely carrying parts of a vanished twin.”

This is due to DNA sequencing being very expensive and time consuming. We are only a few years passed having the human genome sequence. Time will come when our DNA sequence will cost less then 1,000 dollars and can be done as fast and as long as you want it to depending on how many SNPs that need to be sequenced.

]]> By: NA http://www.eyeondna.com/2007/08/16/google-answers-dna-whos-yer-daddy/comment-page-1/#comment-4752 NA Fri, 17 Aug 2007 14:01:21 +0000 http://www.eyeondna.com/2007/08/16/google-answers-dna-whos-yer-daddy/#comment-4752 "Like the woman who’s kids were tested for bone marrow transplant who found that her reproductive organs were that of a vanished fraternal twin (so technically three of her four kids weren’t genetically hers, or they were, if your support of internal organs gives you ownership rights)." One does have ownership rights of their organs. Choosing to be an organ donor or not is ownership. “Like the woman who’s kids were tested for bone marrow transplant who found that her reproductive organs were that of a vanished fraternal twin (so technically three of her four kids weren’t genetically hers, or they were, if your support of internal organs gives you ownership rights).”

One does have ownership rights of their organs. Choosing to be an organ donor or not is ownership.

]]> By: Hsien http://www.eyeondna.com/2007/08/16/google-answers-dna-whos-yer-daddy/comment-page-1/#comment-4704 Hsien Thu, 16 Aug 2007 16:49:31 +0000 http://www.eyeondna.com/2007/08/16/google-answers-dna-whos-yer-daddy/#comment-4704 I am amazed at your wealth of knowledge, NA! Thanks for the great explanation. I am amazed at your wealth of knowledge, NA! Thanks for the great explanation.

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