by Dr. Hsien-Hsien Lei
Posted September 4, 2007 in Personalities with DNA
To much acclaim, J. Craig Venter’s genome was published today in PLoS Biology: The Diploid Genome Sequence of an Individual Human. Huntington F. Willard, a geneticist at Duke University, is calling Craig Venter’s newly published genome sequence the new “gold standard.”
Here are some other comments from around the genetics community on Dr. Venter’s diploid genome – the full complement of the chromosomes he inherited from both his mother and father.
Edward M. Rubin, a genome expert at the Lawrence Berkeley National Laboratory:
I donâ€™t want to fan the fires but I like this, itâ€™s a really good genome.
George Church, Harvard professor and head of the Personal Genome Project:
I would call this a small, quantitative milestone.
Stephen W. Scherer, University of Toronto and co-author of the Venter genome paper:
This is the first time that anyone has had an accurate representation of how much variation there is in a human genome.
With this type of knowledge now in hand, the stage is set for an era of personalized medicine, where genome sequence information becomes a critical reference to assist with health-related decisions.
It’s different from everything we’ve learned … the chromosomes don’t line up at all. You can have no gene on one chromosome and have two copies of the gene on the other … there’s really a more dynamic interplay than we thought.
This is the ultimate form of genealogy. You’ll have incredible information about yourself. I wouldn’t be surprised if Internet-based browsers pop up before long that allow you to compare your genome to others. [Editor's note: Yes, Doctor. That would probably be 23andMe....]
Kathy Siminovitch, director of genomic medicine at Toronto’s Mount Sinai Hospital and the Samuel Lunenfeld Research Insitute:
It seems like it is possible to think that a $1,000 genome could be within reach. When we see how much variation there is in [Dr. Venter's] DNA, then chances are there is this much variation in all DNA. … This publication [of the Venter genome] will drive the momentum to get the price down and to be able to do this on lots of people.
Dr. Venter, the man himself:
It is clear that we are still at the earliest stages of discovery about ourselves and only with continued sequencing of more individual genomes will we be able to garner a full understanding of how our genes influence our lives.
Once we have those [complete genomes], we will basically be able to sort out every fundamental question about nature versus nurture, what’s genetic and what’s environment. [Editor's note: Of course, nurture and the environment feed off of nature and genes. It's an endless feedback loop.]
What we are all going to find out is that, with some very rare exceptions, every human trait is a statistical probability resulting from a number of genes working together.
With this publication we have shown that human-to-human variation is five- to seven-fold greater than earlier estimates, proving that we are in fact more unique at the individual genetic level than we thought.
I’ve not asked any of their [his mother, three siblings, and 30-year-old son] permission, but we’ve discussed it all extensively. Their main response is not “Oh, my God.” It’s “Can I get my genome done, too?”
We don’t need to fear our genetic codes. They are not life or death sentences.
We have all been taught that we should fear this information. We hope to teach people they should welcome it as a breath of fresh air that gives them opportunities in their lives.
Knowing something doesn’t change what’s in our genetic code. But knowing things maybe gives us a chance to change what could be part of our genetic destiny.
More on Dr. J. Craig Venter’s Fabulous Genome...
What comes after genome sequencing?...
Craig Venter on the Sinfest Forum...
Craig Venter’s DNA Star Tarnished...
Personal Genome Sequencing Company Knome Launches...
Nanosphere DNA Test Using Gold Nanoparticles...
DNA Video: Craig Venter on the Charlie Rose Show...
Sorry, the comment form is closed at this time.
Search Eye on DNA
- Genetic Genealogy on Faces of America
- DNA Network Tweet Cloud
- Genetics = Real Science
- Larry David’s DNA Test
- Lopez Tonight First Late-Night Show to Offer DNA Testing
- American Genes Don’t Exist
- Knowledge about Genetic Risk is Power or is it Fear?
- Murderer Gets Reduced Sentence Because His Genes Made Him Do It
- Video: Knome’s Ari Kiirikki Speaks with Medgadget
- DNA Toys: Ben 10 and Digimon Digivice
- 100 Facts About DNA
- Salaries for Jobs in Genetics
- How To Determine Paternity Without A DNA Test
- Fetal Gender DNA Tests Answer Common Pregnancy Question...Or Not
- What does DNA mean to you?
- Eye on DNA Interview: Dr. Tzung-Fu Hsieh of RedTracer DNA Test for the Red Hair Gene, MC1R
- Books About DNA: The Crime of Reason by Robert B. Laughlin
- Genetically Modified Organisms Bring in the Cash
- Navigenics Introduces Physician Portal and Annual Insight Service
- People Who’ve Had Their Genomes Sequenced
09/29/2009 07:03 am
- Larry David’s DNA Test
11/17/2009 02:52 am
- 23andMe DNA Tests for $399, Down From $999
09/10/2008 04:33 am
- Crazy Genetic Marketing Ideas
07/05/2008 09:14 pm
- Parenting Children Using Genetic Tests
05/18/2009 02:09 am
- Business of DNA
- DNA @ Google Answers
- DNA and Disease
- DNA and Genealogy
- DNA and the Law
- DNA Around the World
- DNA Fun
- DNA in General
- DNA Inventions and Gadgets
- DNA Lab Talk
- DNA Podcasts and Videos
- DNA Quotes and Excerpts
- DNA Testing
- Gene Therapy
- Genetic Engineering
- Genetically Modified Foods and Organisms
- Jobs Involving DNA
- Personalities with DNA
- Polls About DNA
- January 2010
- November 2009
- October 2009
- September 2009
- August 2009
- July 2009
- June 2009
- March 2009
- February 2009
- January 2009
- December 2008
- November 2008
- October 2008
- September 2008
- August 2008
- July 2008
- June 2008
- May 2008
- April 2008
- March 2008
- February 2008
- January 2008
- December 2007
- November 2007
- October 2007
- September 2007
- August 2007
- July 2007
- June 2007
- May 2007
- April 2007
- Genes & Drugs Blog
- Flags and Lollipops
- Flu Patrol
- The Inoculated Mind
- Gene Sherpa
- Bio Job Blog