by Dr. Hsien-Hsien Lei
Posted September 14, 2007 in DNA in General
It’s been just over a week since we were all in a tizzy over the sequencing of Craig Venter’s diploid genome and already people are asking, “What next?” And the answer would be: systems biology.
According to Dr. Leroy Hood, president of the the Institute of Systems Biology, systems biology is “the science of discovering, modeling, understanding and ultimately engineering at the molecular level the dynamic relationships between the biological molecules that define living organisms.” And over at new DNA Network member blog, The Seven Stones, Dr. George Church takes the leap from the “Jimome & Craigome” to systems biology. In The Personal Genome Project published in Molecular Systems Biology, Dr. Church said we need the following:
Focused population association studies
Functional genomics on the cells from the subjects
As an epidemiologst, I’m particularly interested in population association studies for which many study participants would be recruited to give a sample of their DNA, submit to a lifestyle survey, and commit to follow-ups. The UK Biobank and CARTaGEne in Quebec, Canada are two such examples (please see previous Eye on DNA post).
In parallel with genome mapping and sequencing, researchers in Europe believe it’s time to start working on a proteome map to delineate which specific genes are producing which specific proteins. Mapping the proteome is considerably more difficult than dealing with the genome because some proteins are present in almost undetectable amounts. It’s also very difficult to know if all proteins have been found if certain genes happen to be inactive at the time of assay.
Professor Rudolf Aebersold from the Institute of Molecular Systems Biology in Switzerland:
The idea would be that if we could map out the whole proteome, we could develop a toolbox structure enabling assays (for detecting proteins) to be done faster and more cheaply.
As you can see, the
work fun doesn’t stop with whole genome sequencing. In fact, it’s just begun.
Photo: Proteomics – protein separation from Wellcome Images under Creative Commons
Craig Venter on the Sinfest Forum...
Personal Genome Sequencing Company Knome Launches...
The Impressive Eucalyptus Tree and Its Genome...
Rich and Famous Line Up for Genome Sequencing...
Eye on DNA Links for 1 August 2007...
Whole Genome Sequencing Costs Continue to Drop...
China Now Exporting Genomic Biotechnology...
Sorry, the comment form is closed at this time.
Search Eye on DNA
- Genetic Genealogy on Faces of America
- DNA Network Tweet Cloud
- Genetics = Real Science
- Larry David’s DNA Test
- Lopez Tonight First Late-Night Show to Offer DNA Testing
- American Genes Don’t Exist
- Knowledge about Genetic Risk is Power or is it Fear?
- Murderer Gets Reduced Sentence Because His Genes Made Him Do It
- Video: Knome’s Ari Kiirikki Speaks with Medgadget
- DNA Toys: Ben 10 and Digimon Digivice
- 100 Facts About DNA
- Salaries for Jobs in Genetics
- How To Determine Paternity Without A DNA Test
- Fetal Gender DNA Tests Answer Common Pregnancy Question...Or Not
- What does DNA mean to you?
- Eye on DNA Interview: Dr. Tzung-Fu Hsieh of RedTracer DNA Test for the Red Hair Gene, MC1R
- Books About DNA: The Crime of Reason by Robert B. Laughlin
- Genetically Modified Organisms Bring in the Cash
- Navigenics Introduces Physician Portal and Annual Insight Service
- People Who’ve Had Their Genomes Sequenced
09/29/2009 07:03 am
- Larry David’s DNA Test
11/17/2009 02:52 am
- 23andMe DNA Tests for $399, Down From $999
09/10/2008 04:33 am
- Crazy Genetic Marketing Ideas
07/05/2008 09:14 pm
- Parenting Children Using Genetic Tests
05/18/2009 02:09 am
- Business of DNA
- DNA @ Google Answers
- DNA and Disease
- DNA and Genealogy
- DNA and the Law
- DNA Around the World
- DNA Fun
- DNA in General
- DNA Inventions and Gadgets
- DNA Lab Talk
- DNA Podcasts and Videos
- DNA Quotes and Excerpts
- DNA Testing
- Gene Therapy
- Genetic Engineering
- Genetically Modified Foods and Organisms
- Jobs Involving DNA
- Personalities with DNA
- Polls About DNA
- January 2010
- November 2009
- October 2009
- September 2009
- August 2009
- July 2009
- June 2009
- March 2009
- February 2009
- January 2009
- December 2008
- November 2008
- October 2008
- September 2008
- August 2008
- July 2008
- June 2008
- May 2008
- April 2008
- March 2008
- February 2008
- January 2008
- December 2007
- November 2007
- October 2007
- September 2007
- August 2007
- July 2007
- June 2007
- May 2007
- April 2007
- Tales of CFS
- Bio Job Blog
- Elefante Jirafa
- The Inoculated Mind
- Biochemist in Exile
- Professor Olsen @Large
- Six Impossible Things Before Breakfast
- Twisted Bacteria
- Dream Mom