Comments on: What comes after genome sequencing? http://www.eyeondna.com/2007/09/14/what-comes-after-genome-sequencing/ How will it change your life? Wed, 08 Oct 2008 03:25:36 +0000 http://wordpress.org/?v=2.5.1 By: Autism and Genetics and the Environment http://www.eyeondna.com/2007/09/14/what-comes-after-genome-sequencing/#comment-12039 Autism and Genetics and the Environment Tue, 09 Oct 2007 23:45:35 +0000 http://www.eyeondna.com/2007/09/14/what-comes-after-genome-sequencing/#comment-12039 [...] death sentence”: As epidemiologist Dr. Hsien-Hsien Lei writes today in regard to systems biology, which considered the “overall picture of how genes interact with each other and with the [...] [...] death sentence”: As epidemiologist Dr. Hsien-Hsien Lei writes today in regard to systems biology, which considered the “overall picture of how genes interact with each other and with the [...]

]]> By: Hsien-Hsien Lei, PhD http://www.eyeondna.com/2007/09/14/what-comes-after-genome-sequencing/#comment-9072 Hsien-Hsien Lei, PhD Sun, 16 Sep 2007 09:48:00 +0000 http://www.eyeondna.com/2007/09/14/what-comes-after-genome-sequencing/#comment-9072 Thanks for the useful links, Thomas! I still remember when I first across the term metabonomics. Here's an excerpt of something I wrote back in May 2006: <i>Today’s new word is pharmaco-metabonomics - personalized medicine that takes into account how environmental factors interact with the unique way each person metabolizes drugs. Metabonomics is also known as metabolomics (both are impossible to pronounce). The combination of pharmaco-metabonomics and pharmacogenomics should make it possible to develop the ultimate personalized medicine.</i> Thanks for the useful links, Thomas! I still remember when I first across the term metabonomics. Here’s an excerpt of something I wrote back in May 2006:

Today’s new word is pharmaco-metabonomics - personalized medicine that takes into account how environmental factors interact with the unique way each person metabolizes drugs. Metabonomics is also known as metabolomics (both are impossible to pronounce). The combination of pharmaco-metabonomics and pharmacogenomics should make it possible to develop the ultimate personalized medicine.

]]> By: Hsien-Hsien Lei, PhD http://www.eyeondna.com/2007/09/14/what-comes-after-genome-sequencing/#comment-9071 Hsien-Hsien Lei, PhD Sun, 16 Sep 2007 09:46:02 +0000 http://www.eyeondna.com/2007/09/14/what-comes-after-genome-sequencing/#comment-9071 DNA News, Thanks for the comment. Couldn't agree with you more. DNA News, Thanks for the comment. Couldn’t agree with you more.

]]> By: Thomas http://www.eyeondna.com/2007/09/14/what-comes-after-genome-sequencing/#comment-8883 Thomas Fri, 14 Sep 2007 22:59:28 +0000 http://www.eyeondna.com/2007/09/14/what-comes-after-genome-sequencing/#comment-8883 Many thanks, Hsien-Hsien, for this post and for highlighting George Church's post on The Seven Stones. I find the concept of personal <i>functional</i> genomics applied to (personal) stem cells an absolutely fascinating perspective. When will these technologies be applied to the scale required for molecular epidemiology? Time will tell. But it is clear that new technologies will be needed that are adapted to the large scale phenotyping (at the biochemical/molecular level) of human populations. In this sense, the field of <a href="http://www.medterms.com/script/main/art.asp?articlekey=38634">metabonomics</a> might be a promising avenue and may in fact extend the application of systems biology to personalized medicine and molecular epidemiology beyond the fields of genomics and genetics (<a href="http://www.nature.com/msb/journal/v2/n1/full/msb4100095.html">Global systems biology, personalized medicine and molecular epidemiology, Nicholson, 2006</a>). Many thanks, Hsien-Hsien, for this post and for highlighting George Church’s post on The Seven Stones.

I find the concept of personal functional genomics applied to (personal) stem cells an absolutely fascinating perspective.

When will these technologies be applied to the scale required for molecular epidemiology? Time will tell. But it is clear that new technologies will be needed that are adapted to the large scale phenotyping (at the biochemical/molecular level) of human populations. In this sense, the field of metabonomics might be a promising avenue and may in fact extend the application of systems biology to personalized medicine and molecular epidemiology beyond the fields of genomics and genetics (Global systems biology, personalized medicine and molecular epidemiology, Nicholson, 2006).

]]> By: DNA News http://www.eyeondna.com/2007/09/14/what-comes-after-genome-sequencing/#comment-8852 DNA News Fri, 14 Sep 2007 17:46:10 +0000 http://www.eyeondna.com/2007/09/14/what-comes-after-genome-sequencing/#comment-8852 Our ability to generate vast amounts of DNA sequences is clearly going well beyond our ability to analyse it, perhaps at a exponential vs linear ratio. Systems biology is still a fuzzy subject, but it needs lots of support if we want to be able to take full advantage of the enormous quantity of information we are gathering through genome projects Our ability to generate vast amounts of DNA sequences is clearly going well beyond our ability to analyse it, perhaps at a exponential vs linear ratio. Systems biology is still a fuzzy subject, but it needs lots of support if we want to be able to take full advantage of the enormous quantity of information we are gathering through genome projects

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