2007 Nobel Prize in Medicine Goes To Mice Geneticists

2007 Nobel Prize in Medicine Goes To Mice Geneticists

by Dr. Hsien-Hsien Lei
Posted October 8, 2007 in DNA Lab Talk, Genetic Engineering

Congratulations to Mario R. Capecchi, Oliver Smithies, and Sir Martin J Evans who won the 2007 Nobel Prize in medicine today! The announcement was made just minutes ago and their pictures aren’t even up on the Nobel Prize site yet.

The 2007 Nobel Prize in Physiology or Medicine goes to Mario R. Capecchi, Martin J. Evans, and Oliver Smithies for their discoveries of principles for introducing specific gene modifications in mice by the use of embryonic stem cells.

The three Nobel Laureates pioneered gene targeting in mice which can be used to inactivate single genes to create “knockout” mice. Over ten thousand mouse genes have been knocked out and studied thus far and over five hundred different mouse models of human disorders have been created.

knockout mice

More about the fascinating gene-targeting experiments in the Nobel Prize Press Release.

Photo: Knockout mice from Wellcome Images under Creative Commons

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(7 comments)


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7 Comments

Comment by NA Subscribed to comments via email

I’m surprised this type of work is Nobel worthy! Congrats to them! What matters most is that they have developed technology that has lead to mouse models of human diseases. Knocking out genes is nice, but understanding the role that the gene has in the development of the disease more important. Without understanding the function of the gene, we won’t fully understand the protein function.

Hi NA, I am certainly not one to judge what is or is not Nobel worthy. However, figuring out that homologous recombination can be used to introduce new genetic material into a mammalian genome and the use of embryonic stem cells to introduce genes into the germ line are not small accomplishments!

 
 

[...] Competition by Dr. Hsien-Hsien Lei Posted October 8, 2007 in DNA Fun Following up on today’s announcement of the Nobel Prize for medicine , here’s the 2007 Nikon Small World Photomicrography Competition 1st place winner: Double [...]

 

[...] What is the Importance of New Discoveries? The three Nobel Laureates pioneered gene targeting in mice which can be used to inactivate single genes to create “knockout” mice. Over ten thousand mouse genes have been knocked out and studied thus far and over five hundred different mouse models of human disorders have been created. quoted from eyeondna.com [...]

 

[...] 2007 Nobel Prize in Medicine Goes To Mice Geneticists (Eye on DNA) [...]

 
Comment by Barry Starr Subscribed to comments via email

I am glad to see that a bit of important basic research won the prize. Knockout mice are so important for, well, nearly everything. Did they have anything to do with knock in technology as well?

 
Comment by NA

Just wanted to share some thoughts I saw elsewhere on the matter:
http://pacificresearch.org/blog/id.191/blog_detail.asp

 

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