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	<title>Comments on: Genetics of Bipolar Disorder and Hypomania</title>
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	<link>http://www.eyeondna.com/2007/10/11/genetics-of-bipolar-disorder-and-hypomania/</link>
	<description>How will it change your life?</description>
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		<title>By: Genetics And Bipolar Disorder: Talk Shop With Dr. Melvin G. McInnis</title>
		<link>http://www.eyeondna.com/2007/10/11/genetics-of-bipolar-disorder-and-hypomania/comment-page-1/#comment-56782</link>
		<dc:creator>Genetics And Bipolar Disorder: Talk Shop With Dr. Melvin G. McInnis</dc:creator>
		<pubDate>Mon, 26 May 2008 16:02:01 +0000</pubDate>
		<guid isPermaLink="false">http://www.eyeondna.com/2007/10/11/genetics-of-bipolar-disorder-and-hypomania/#comment-56782</guid>
		<description>[...] October, Dr. Hsien-Hsien Lei of Eye On DNA highlighted information regarding bipolar disorder and genetics (and published a picture of me wearing the exact tee shirt I&#8217;m wearing right now - funny, [...]</description>
		<content:encoded><![CDATA[<p>[...] October, Dr. Hsien-Hsien Lei of Eye On DNA highlighted information regarding bipolar disorder and genetics (and published a picture of me wearing the exact tee shirt I&#8217;m wearing right now &#8211; funny, [...]</p>
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		<title>By: Kaila Colbin</title>
		<link>http://www.eyeondna.com/2007/10/11/genetics-of-bipolar-disorder-and-hypomania/comment-page-1/#comment-44454</link>
		<dc:creator>Kaila Colbin</dc:creator>
		<pubDate>Thu, 07 Feb 2008 02:36:29 +0000</pubDate>
		<guid isPermaLink="false">http://www.eyeondna.com/2007/10/11/genetics-of-bipolar-disorder-and-hypomania/#comment-44454</guid>
		<description>Hi there,

In light of Andro&#039;s observation, may I ask whether the &#039;20 percent chance&#039; from two bipolar parents is a hard number or whether it is 20% &lt;em&gt;higher&lt;/em&gt;?

Cheers,
Kaila</description>
		<content:encoded><![CDATA[<p>Hi there,</p>
<p>In light of Andro&#8217;s observation, may I ask whether the &#8216;20 percent chance&#8217; from two bipolar parents is a hard number or whether it is 20% <em>higher</em>?</p>
<p>Cheers,<br />
Kaila</p>
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		<title>By: Genetic Testing for Psychiatric Diseases</title>
		<link>http://www.eyeondna.com/2007/10/11/genetics-of-bipolar-disorder-and-hypomania/comment-page-1/#comment-44206</link>
		<dc:creator>Genetic Testing for Psychiatric Diseases</dc:creator>
		<pubDate>Wed, 06 Feb 2008 10:54:45 +0000</pubDate>
		<guid isPermaLink="false">http://www.eyeondna.com/2007/10/11/genetics-of-bipolar-disorder-and-hypomania/#comment-44206</guid>
		<description>[...] NB: Andro Hsu of 23andMe has made a similar point in the past about presenting risk information. [...]</description>
		<content:encoded><![CDATA[<p>[...] NB: Andro Hsu of 23andMe has made a similar point in the past about presenting risk information. [...]</p>
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		<title>By: Hsien-Hsien Lei, PhD</title>
		<link>http://www.eyeondna.com/2007/10/11/genetics-of-bipolar-disorder-and-hypomania/comment-page-1/#comment-12368</link>
		<dc:creator>Hsien-Hsien Lei, PhD</dc:creator>
		<pubDate>Fri, 12 Oct 2007 08:15:33 +0000</pubDate>
		<guid isPermaLink="false">http://www.eyeondna.com/2007/10/11/genetics-of-bipolar-disorder-and-hypomania/#comment-12368</guid>
		<description>Alicia, You rock! I&#039;m so impressed at how well you&#039;re handling everything. I definitely think you&#039;re on to greater and greater successes.</description>
		<content:encoded><![CDATA[<p>Alicia, You rock! I&#8217;m so impressed at how well you&#8217;re handling everything. I definitely think you&#8217;re on to greater and greater successes.</p>
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	<item>
		<title>By: Hsien-Hsien Lei, PhD</title>
		<link>http://www.eyeondna.com/2007/10/11/genetics-of-bipolar-disorder-and-hypomania/comment-page-1/#comment-12367</link>
		<dc:creator>Hsien-Hsien Lei, PhD</dc:creator>
		<pubDate>Fri, 12 Oct 2007 08:13:43 +0000</pubDate>
		<guid isPermaLink="false">http://www.eyeondna.com/2007/10/11/genetics-of-bipolar-disorder-and-hypomania/#comment-12367</guid>
		<description>Thanks for making that great point, Andro. It would be a perfect blog post! When are you going to get that going? ;)</description>
		<content:encoded><![CDATA[<p>Thanks for making that great point, Andro. It would be a perfect blog post! When are you going to get that going? <img src='http://www.eyeondna.com/wp-includes/images/smilies/icon_wink.gif' alt=';)' class='wp-smiley' /> </p>
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		<title>By: alicia</title>
		<link>http://www.eyeondna.com/2007/10/11/genetics-of-bipolar-disorder-and-hypomania/comment-page-1/#comment-12332</link>
		<dc:creator>alicia</dc:creator>
		<pubDate>Fri, 12 Oct 2007 03:20:30 +0000</pubDate>
		<guid isPermaLink="false">http://www.eyeondna.com/2007/10/11/genetics-of-bipolar-disorder-and-hypomania/#comment-12332</guid>
		<description>&lt;strong&gt;Hsien&lt;/strong&gt;: You make me blush.

Right before the event that led to my finally seeing a professional, and eventually getting diagnosed, I was hypomanic for...geez...well, a long time. Severely, then not-so-severely, then manic, then hypo again. I was mostly hypo for years. It was...well, at the time it was wonderful. I worked 2 jobs (one was my actual full-time career, the other was a job I picked up in college and just couldn&#039;t give up?!), 6 or 7 days/nights a week, slept 2-3 hours a night/morning, and managed to have a...very &quot;interesting&quot; social life. I felt like everything I touched turned to gold, because everything was so successful. Of course, I was on the eve of mania, then crashing, then total disaster.

I&#039;m now stuck in knowing how good it can be, how bad it can turn, and not knowing how to get back to it even if I knew how to balance it. 

But, I&#039;m getting off on a tangent.

Ah, I can&#039;t wait to dig into these links! Thank you so much!

&lt;strong&gt;Andro&lt;/strong&gt;: &lt;em&gt;Excellent&lt;/em&gt; observation.</description>
		<content:encoded><![CDATA[<p><strong>Hsien</strong>: You make me blush.</p>
<p>Right before the event that led to my finally seeing a professional, and eventually getting diagnosed, I was hypomanic for&#8230;geez&#8230;well, a long time. Severely, then not-so-severely, then manic, then hypo again. I was mostly hypo for years. It was&#8230;well, at the time it was wonderful. I worked 2 jobs (one was my actual full-time career, the other was a job I picked up in college and just couldn&#8217;t give up?!), 6 or 7 days/nights a week, slept 2-3 hours a night/morning, and managed to have a&#8230;very &#8220;interesting&#8221; social life. I felt like everything I touched turned to gold, because everything was so successful. Of course, I was on the eve of mania, then crashing, then total disaster.</p>
<p>I&#8217;m now stuck in knowing how good it can be, how bad it can turn, and not knowing how to get back to it even if I knew how to balance it. </p>
<p>But, I&#8217;m getting off on a tangent.</p>
<p>Ah, I can&#8217;t wait to dig into these links! Thank you so much!</p>
<p><strong>Andro</strong>: <em>Excellent</em> observation.</p>
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		<title>By: Mental Health Awareness Days Abound!</title>
		<link>http://www.eyeondna.com/2007/10/11/genetics-of-bipolar-disorder-and-hypomania/comment-page-1/#comment-12330</link>
		<dc:creator>Mental Health Awareness Days Abound!</dc:creator>
		<pubDate>Fri, 12 Oct 2007 03:03:59 +0000</pubDate>
		<guid isPermaLink="false">http://www.eyeondna.com/2007/10/11/genetics-of-bipolar-disorder-and-hypomania/#comment-12330</guid>
		<description>[...] Lei gave me and bipolar disorder an awesome shout out today at her fabulous blog Eye on DNA: Genetics of Bipolar Disorder and Hypomania. (Is &#8220;shout out&#8221; the appropriate term to use when one refers to information about and [...]</description>
		<content:encoded><![CDATA[<p>[...] Lei gave me and bipolar disorder an awesome shout out today at her fabulous blog Eye on DNA: Genetics of Bipolar Disorder and Hypomania. (Is &#8220;shout out&#8221; the appropriate term to use when one refers to information about and [...]</p>
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		<title>By: Andro Hsu</title>
		<link>http://www.eyeondna.com/2007/10/11/genetics-of-bipolar-disorder-and-hypomania/comment-page-1/#comment-12301</link>
		<dc:creator>Andro Hsu</dc:creator>
		<pubDate>Thu, 11 Oct 2007 22:39:28 +0000</pubDate>
		<guid isPermaLink="false">http://www.eyeondna.com/2007/10/11/genetics-of-bipolar-disorder-and-hypomania/#comment-12301</guid>
		<description>Hi Hsien,

I&#039;ve been reading &lt;i&gt;The Tiger That Isn&#039;t&lt;/i&gt;, a book about innumeracy (the numerical version of illiteracy).  It&#039;s sort of an updated version of the classic &lt;i&gt;How To Lie With Statistics&lt;/i&gt;, but with an eye toward the mainstream media (MSM) and public policy.

In the chapter on risk, the authors point out that the MSM often reports increases in risk as &quot;70% higher&quot; without reporting the baseline or average risk.  They suggest that skeptical (or just honest) readers should ask, &quot;70% compared to what?&quot;

The &lt;a href=&quot;http://www.nimh.nih.gov/health/publications/the-numbers-count-mental-disorders-in-america.shtml#Bipolar&quot;&gt;NIMH&lt;/a&gt; reports that the adult prevalence of bipolar disorder is 2.6%.  So the authors of &lt;i&gt;Tiger&lt;/i&gt; would suggest that MSM reports read more like the following:

&quot;The average American has a 2.6% chance of having bipolar disorder. Siblings with an identical twin who has bipolar disorder have a 4.4% chance. People who have one parent with bipolar disorder have a 2.8-2.9% chance of becoming bipolar, while those with two bipolar parents have a 3.1% chance.&quot;

Why does the MSM like to report it the first way?  Simply because normalizing against the average risk makes bigger numbers and sells more papers/airtime/adclicks! A &quot;20% increase&quot; sounds much more serious than having a 3.1% chance compared to a 2.6% chance, even though they mean exactly the same thing.

Reporting the baseline risk is important because it underscores the fact that even though there may be a genetic component to conditions like bipolar disorder, genetics are not deterministic for many of the most common diseases.

Andro</description>
		<content:encoded><![CDATA[<p>Hi Hsien,</p>
<p>I&#8217;ve been reading <i>The Tiger That Isn&#8217;t</i>, a book about innumeracy (the numerical version of illiteracy).  It&#8217;s sort of an updated version of the classic <i>How To Lie With Statistics</i>, but with an eye toward the mainstream media (MSM) and public policy.</p>
<p>In the chapter on risk, the authors point out that the MSM often reports increases in risk as &#8220;70% higher&#8221; without reporting the baseline or average risk.  They suggest that skeptical (or just honest) readers should ask, &#8220;70% compared to what?&#8221;</p>
<p>The <a href="http://www.nimh.nih.gov/health/publications/the-numbers-count-mental-disorders-in-america.shtml#Bipolar">NIMH</a> reports that the adult prevalence of bipolar disorder is 2.6%.  So the authors of <i>Tiger</i> would suggest that MSM reports read more like the following:</p>
<p>&#8220;The average American has a 2.6% chance of having bipolar disorder. Siblings with an identical twin who has bipolar disorder have a 4.4% chance. People who have one parent with bipolar disorder have a 2.8-2.9% chance of becoming bipolar, while those with two bipolar parents have a 3.1% chance.&#8221;</p>
<p>Why does the MSM like to report it the first way?  Simply because normalizing against the average risk makes bigger numbers and sells more papers/airtime/adclicks! A &#8220;20% increase&#8221; sounds much more serious than having a 3.1% chance compared to a 2.6% chance, even though they mean exactly the same thing.</p>
<p>Reporting the baseline risk is important because it underscores the fact that even though there may be a genetic component to conditions like bipolar disorder, genetics are not deterministic for many of the most common diseases.</p>
<p>Andro</p>
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