by Dr. Hsien-Hsien Lei
Posted December 11, 2007 in DNA Testing
Contrary to what you may see in the media, genetic tests are not as common as toothbrushes even if some can now be found in drug stores. Currently, most genetic testing companies offer their tests in only a few ways – via the Web or through physician referral to genetic counselors. This means that most people have no idea that genetic testing is readily available and that they can, on their own initiative, choose to undergo testing for genealogy, ancestry, medical genetics, or simply for fun.
For people new to this whole genetic testing “game,” I offer the following advice. Although you can’t change your DNA, it is possible to prep yourself for a DNA test just as it’s possible to prep yourself for a driving test. It is critically important that anyone undergoing DNA testing learn as much as they can about the results they can expect to receive, the interpretation of these results, and the impact results may have on their life choices.
Do your research. Decide on the TYPE of genetic test you want before you choose the testing company. For most people, this will be fairly straightforward once they poke around a bit online. Those interested in genealogy and filling in their family tree will go for Y-DNA, mtDNA testing, or perhaps even paternity testing. Those wondering if they are at risk of specific inherited diseases will select medical genetic testing. And those who are savvy and interested in learning more about the whole genomes will select SNP scans or sequencing. Most importantly, find out what specific genetic markers, genes, or SNPs will be examined for the genetic test you choose.
Choose the genetic testing company that offers the best customer support and service. Bargain shoppers will cringe but genetic testing is not an area where I’d recommend going cheap. There is a reason certain paternity testing companies offer testing for $99; perhaps their labs are not CLIA certified or they do not offer much information beyond the most basic data. Choose a company that has created an easy to navigate website with educational information to answer any questions you may have, including laboratory accreditations. Their contact info should be easy to find and they should respond to customer emails within the day. Better yet, they should list a phone number so you can get immediate responses to your queries. Do a Google search using the company name to see what kind of press reports have been written about them. Also do a Google blog search to see what blogging customers have said about their experiences.
Consider the possibility that you may get unexpected results. There have been cases where people undergoing ancestry/genealogy DNA testing find surprising family connections, e.g., non-paternity event. How would you react to such results? Would you share the news with your family members? If you’ve been raised Jewish, how would you feel if your results showed that you had no “Jewish DNA”? Even if you have no family history of heart disease, how will you change your life if you carry a gene that increases your risk of the disease? Will you feel guilty even if you decide to continue on as before?
Would you share the results of your genetic test with family, friends, and healthcare providers? Finding out you have the gene/SNP for a particular medical condition implicates not just yourself but your parents, siblings, and children. There is a chance that if you test positive for the ovarian and breast cancer gene, BRCA, your relatives may have the same gene that increases their risk of these cancers. Will you be telling everyone that you’ve signed up for genetic testing? And if so, will you be sharing your results? How might this affect the choices you make for not just yourself, but your children? Would you tell your physician if you carry a disease-causing gene?
Understand that results from DNA testing are not always definitive or diagnostic. The way I think of it, genetic tests pull back the corner of a heavy curtain. The results give you a hint, a clue as to where you should consider paying more attention. In most cases, having the SNP that predisposes you to type 2 diabetes, for example, does not guarantee you will develop it in your lifetime. Lifestyle factors, such as diet and exercise, also contribute to your risk of developing the disease. And when it comes to genealogy DNA testing, a DNA test can give you a general idea of where your ancestors come from and the other customers who have similar DNA profiles but you will still need to use traditional methods of filling out the details of your family tree, such as birth certificates and death records.
Taking a genetic test can be a cool, fun, and informative way to learn more about your genetic heritage in terms of both family relationships and medical history. But the decision to undergo genetic testing should be backed by independent research and the understanding of the power and lack of power results will have over your life. If you’re ready to take the plunge, you should have confidence that the testing company you choose will support you in your quest for knowledge and will give you any answers you may need.
Approaching genetic testing in a serious and thoughtful manner will ensure that you get the most out of your experience. Although there is much about DNA we still do not understand, there is already much we can learn. Kept in perspective, your foray into genetic testing can be one of the most rewarding experiences you will ever have. Good luck!
Nurse Kendra James Takes The deCODE T2 DNA Test...
Genetics Websites from Harvard University and the World Health Organization...
Yay or Nay for Genetic Testing?...
Commercials for Myriad BRACAnalysis Genetic Test Under Scrutiny...
Fetal Gender DNA Tests Answer Common Pregnancy Question…Or Not...
American Clinical Laboratory Association Tips for Consumers of Genetic Tests...
10 Reasons NOT To Take a DNA Test...
Sorry, the comment form is closed at this time.
Search Eye on DNA
- Genetic Genealogy on Faces of America
- DNA Network Tweet Cloud
- Genetics = Real Science
- Larry David’s DNA Test
- Lopez Tonight First Late-Night Show to Offer DNA Testing
- American Genes Don’t Exist
- Knowledge about Genetic Risk is Power or is it Fear?
- Murderer Gets Reduced Sentence Because His Genes Made Him Do It
- Video: Knome’s Ari Kiirikki Speaks with Medgadget
- DNA Toys: Ben 10 and Digimon Digivice
- 100 Facts About DNA
- Salaries for Jobs in Genetics
- Fetal Gender DNA Tests Answer Common Pregnancy Question...Or Not
- How To Determine Paternity Without A DNA Test
- What does DNA mean to you?
- Eye on DNA Interview: Dr. Tzung-Fu Hsieh of RedTracer DNA Test for the Red Hair Gene, MC1R
- Books About DNA: The Crime of Reason by Robert B. Laughlin
- Genetically Modified Organisms Bring in the Cash
- Navigenics Introduces Physician Portal and Annual Insight Service
- People Who’ve Had Their Genomes Sequenced
09/29/2009 07:03 am
- Larry David’s DNA Test
11/17/2009 02:52 am
- 23andMe DNA Tests for $399, Down From $999
09/10/2008 04:33 am
- Crazy Genetic Marketing Ideas
07/05/2008 09:14 pm
- Parenting Children Using Genetic Tests
05/18/2009 02:09 am
- Business of DNA
- DNA @ Google Answers
- DNA and Disease
- DNA and Genealogy
- DNA and the Law
- DNA Around the World
- DNA Fun
- DNA in General
- DNA Inventions and Gadgets
- DNA Lab Talk
- DNA Podcasts and Videos
- DNA Quotes and Excerpts
- DNA Testing
- Gene Therapy
- Genetic Engineering
- Genetically Modified Foods and Organisms
- Jobs Involving DNA
- Personalities with DNA
- Polls About DNA
- January 2010
- November 2009
- October 2009
- September 2009
- August 2009
- July 2009
- June 2009
- March 2009
- February 2009
- January 2009
- December 2008
- November 2008
- October 2008
- September 2008
- August 2008
- July 2008
- June 2008
- May 2008
- April 2008
- March 2008
- February 2008
- January 2008
- December 2007
- November 2007
- October 2007
- September 2007
- August 2007
- July 2007
- June 2007
- May 2007
- April 2007
- Science With Me!
- DNA Direct Talk
- Yann Klimentidis’ Weblog
- Health News Blog
- Flags and Lollipops
- Baby Biotechs
- The Personal Genome