Opaldia to Offer Diagenic Breast Cancer Genetic Test

by Dr. Hsien-Hsien Lei
Posted December 18, 2007 in DNA Testing, DNA and Disease

UK genetic testing company Opaldia will be offering the Diagenic breast cancer blood test starting in 2008. The test detects gene expression patterns in peripheral (circulating) blood and is touted as being able to diagnose asymptomatic breast cancer before it can be detected by manual breast exam or mammograms. In 2005, Diagenic company researchers published an article in Breast Cancer Research detailing 37 predictive genes for breast cancer (pdf).

Dr. James Mackay, Opaldia Medical Director:

I think it is really important to investigate better ways of detecting early breast cancer in young women.

All health professionals who work with breast cancer are concerned that mammograms may be sub optimal in young women under 47. Therefore a new test used alongside mammography would provide the optimal chance of detecting the cancer as early as possible.

Analyzing gene expression signatures from peripheral blood is based on the following principles (adapted from the Diagenic website):

• The body responds to disease in a way that can be detected by measuring the amount of mRNA transcribed from a specific set of genes associated with disease
• These gene expression patterns can be analyzed using whole genome microarrays
• Gene expression signatures can be used to diagnose disease

Diagenic also offers a similar test for Alzheimer’s Disease.

NB: Opaldia CEO Elaine Warburton blogs about their partnership with Diagenic at Genetics and Health.

via Medgadget

Tags: genetics, genes, dna, breast cancer, opaldia, diagenic

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2 Comments »

Pingback by Steps Forward in Clinical Genetics « ScienceRoll

2007-12-29 17:26:28

[...] Hsien-Hsien Lei at Eye on DNA presented Opaldia, a genetic testing company that will offer the Diagenic breast cancer blood test [...]

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Pingback by Happy 2008! | And Briefly About 2007 « www.cancer-genetics.com

2007-12-31 17:49:16

[...] from peripheral blood (by DiaGenic) will be offered in UK by Opaldia from 2008 (also covered by EyeOnDna, GeneticsAndHealth and [...]

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