by Dr. Hsien-Hsien Lei
Posted February 11, 2008 in DNA Inventions and Gadgets, DNA Testing, DNA in General
One of the cheapest going prices for whole human genome sequencing has been set by Illumina at $100,000 with completion time of less than four weeks. Last year, 454 Life Sciences claimed a complete sequence in two months at around $1 million.
While Illumina and 454 Life Sciences (Roche) are considered by some to be leaders of the pack, Dr. Jonathan Eisen of The Tree of Life says competitors are emerging, including ABI and Helicos. Helicos BioSciences has received its first order for the Helicos Genetic Analysis System that includes HeliScope Single Molecule Sequencer, the HeliScope Analysis Engine, and the HeliScope Sample Loader.
Even as sequencing becomes cheaper and more efficient, Dr. Eisen reminds us of two considerations: data management and analysis as well as linking gene sequence to function. Writing from the Advances in Genome Biology and Technology conference in Marco Island, FL, Dr. Eisen:
Function and process have been replaced by terms like “systems biology” and “SNPs” and “networks” and “massively parallel.” We have in a way regressed in terms of treating organisms (or communities) as a black box. Fine scale detail has been lost in a sea of data.
Regardless, the big race now is towards the $1,000 genome and the Archon X PRIZE for Genomics. The first team to sequence 100 human genomes in 10 days for $10,000 or less per genome will win $10 million.
To aid in the sequencing of genomes, Pacific Biosciences aka PacBio is developing a “transformative DNA sequencing platform.” Their machines can read more bases at one go than others.
PacBio – 1,000+ bases
Human Genome Project – 800+ bases
Illumina – 30-50 bases
454 Life Sciences – 200 to 450 bases
PacBio expects to begin selling machines in 2010 with second-generation machines that can perform $1,000 whole genome sequencing available in 2013. The New York Times has a profile of the company and their technology (Dr. Eisen has more). Other companies mentioned were Intelligent Bio-Systems, NABsys, VisiGen Biotechnologies, and Complete Genomics.
Although the â€œ$1,000 genomeâ€ is a purely arbitrary goal, itâ€™s become a Holy Grail of sorts for the genomics field. (The startup Knome, which we covered here, currently offers full-genome sequencing for $350,000.) Cheap, fast sequencing of all six billion DNA â€œletters,â€ or bases, in humans could make it possible, for instance, for doctors to better tailor treatments to a patientâ€™s own genetic quirks or to identify the specific weaknesses of tumor cells. More broadly, it would also vastly increase our understanding of the genome, which has turned out to be a much more mysterious realm than just about anyone expected only a decade ago, and illuminate the ways DNA varies between individuals, groups and even among cells and tissues within a single individual.
There’s obviously a lot of DNA sequencing going on and it’s not limited to the US. Medical Solutions has become the UK’s first commercial provider of Illumina’s DNA sequencing and genotyping platforms – Genome Analyzer and Infinium on the BeadStation platform, respectively.
NB: Jonathan Eisen, David Hamilton, Misha Angrist, and I are all members of The DNA Network .
deCODE CEO Predicts Downswing in Personal Genomics Market...
Personal Genome Sequencing Company Knome Launches...
Craig Venter on the Sinfest Forum...
China Now Exporting Genomic Biotechnology...
DNA Direct Launches DNA Archive for Home DNA Storage...
Get Your Personal Genome Decoded Here...
What comes after genome sequencing?...
Sorry, the comment form is closed at this time.
Search Eye on DNA
- Genetic Genealogy on Faces of America
- DNA Network Tweet Cloud
- Genetics = Real Science
- Larry David’s DNA Test
- Lopez Tonight First Late-Night Show to Offer DNA Testing
- American Genes Don’t Exist
- Knowledge about Genetic Risk is Power or is it Fear?
- Murderer Gets Reduced Sentence Because His Genes Made Him Do It
- Video: Knome’s Ari Kiirikki Speaks with Medgadget
- DNA Toys: Ben 10 and Digimon Digivice
- 100 Facts About DNA
- Salaries for Jobs in Genetics
- Fetal Gender DNA Tests Answer Common Pregnancy Question...Or Not
- What does DNA mean to you?
- Eye on DNA Interview: Dr. Tzung-Fu Hsieh of RedTracer DNA Test for the Red Hair Gene, MC1R
- Books About DNA: The Crime of Reason by Robert B. Laughlin
- Genetically Modified Organisms Bring in the Cash
- Navigenics Introduces Physician Portal and Annual Insight Service
- How To Determine Paternity Without A DNA Test
- People Who’ve Had Their Genomes Sequenced
09/29/2009 07:03 am
- Larry David’s DNA Test
11/17/2009 02:52 am
- 23andMe DNA Tests for $399, Down From $999
09/10/2008 04:33 am
- Crazy Genetic Marketing Ideas
07/05/2008 09:14 pm
- Parenting Children Using Genetic Tests
05/18/2009 02:09 am
- Business of DNA
- DNA @ Google Answers
- DNA and Disease
- DNA and Genealogy
- DNA and the Law
- DNA Around the World
- DNA Fun
- DNA in General
- DNA Inventions and Gadgets
- DNA Lab Talk
- DNA Podcasts and Videos
- DNA Quotes and Excerpts
- DNA Testing
- Gene Therapy
- Genetic Engineering
- Genetically Modified Foods and Organisms
- Jobs Involving DNA
- Personalities with DNA
- Polls About DNA
- January 2010
- November 2009
- October 2009
- September 2009
- August 2009
- July 2009
- June 2009
- March 2009
- February 2009
- January 2009
- December 2008
- November 2008
- October 2008
- September 2008
- August 2008
- July 2008
- June 2008
- May 2008
- April 2008
- March 2008
- February 2008
- January 2008
- December 2007
- November 2007
- October 2007
- September 2007
- August 2007
- July 2007
- June 2007
- May 2007
- April 2007
- MRSA Notes
- Adventures in Ethics and Science
- Mark’s Daily Apple
- World Science
- Science With Me!